Fluconazole and Alcohol You should avoid or limit drinking alcohol while taking fluconazole. Since both can cause headaches and stomach discomfort, drinking alcohol while taking fluconazole may. Helpful answers from Doctors anytime, anywhere: Dr. Saghafi discusses the uses and doses of fluconazole, and whether or not it interacts with alcohol. Both fluconazole and alcohol (beverage) can increase the risk of hepatotoxicity. Can I Take Diflucan With Alcohol? Diflucan is an antifungal or antibiotic medication used to treat fungal infections such as candidiasis, thrush, yeast infections, skin and nail fungal infections, and ringworm. Les études d'interaction ont montré que lorsque le fluconazole est administré par voie orale avec de la nourriture, de la cimétidine, des antiacides ou à la suite de l'irradiation corporelle totale pour greffe de moelle osseuse, aucune altération cliniquement significative de l'absorption du fluconazole n'a été observée. beta carotene is safe at all doses) According to the April 1996 New England Journal of Medicine, the most common cause of acute liver failure in the United States is the negative interaction between acetaminophen (Tylenol) and alcohol. Fluconazole can slow down the removal of other medications from your body, which can affect how they work. Examples of affected drugs include asunaprevir, cisapride, among others. Talk with your doctor before you drink alcohol. This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking this medicine (fluconazole tablets) with your other drugs. Very bad skin problems like rashes have happened with this medicine (fluconazole tablets. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.